Contrasting dynamic and mechanistic signatures of Class 3 and Class 4 neutralizing antibodies targeting SARS-CoV-2 spike protein: dissecting molecular determinants of neutralization mechanisms using a multi-pronged computational approach
- 30 September 2026
- journal article
- Published by Royal Society of Chemistry (RSC) in Physical Chemistry Chemical Physics
- Vol. 28 (37) , 23108-23135
Abstract
Neutralizing antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) exhibit distinct patterns of potency, breadth, and resilience, yet the molecular mechanisms underlying these differences remain incompletely understood.Keywords
Funding Information
- National Institutes of Health (1R01AI181600-01)
- National Institutes of Health (5R01AI181600-02)
- National Institutes of Health (Subaward 6069-SC24-11)
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