Does Mitochondrial DNA Play a Role in Parkinson's Disease? A Review of Cybrid and Other Supportive Evidence
- 1 May 2012
- journal article
- review article
- Published by SAGE Publications in Antioxidants & Redox Signaling
- Vol. 16 (9) , 950-964
Abstract
Significance: Mitochondria are currently believed to play an important role in the neurodysfunction and neurodegeneration that underlie Parkinson's disease (PD). Recent Advances: While it increasingly appears that mitochondrial dysfunction in PD can have different causes, it has been proposed that mitochondrial DNA (mtDNA) may account for or drive mitochondrial dysfunction in the majority of the cases. If correct, the responsible mtDNA signatures could represent acquired mutations, inherited mutations, or population-distributed polymorphisms. Critical Issues and Future Directions: This review discusses the case for mtDNA as a key mediator of PD, and especially focuses on data from studies of PD cytoplasmic hybrid (cybrid) cell lines. Antioxid. Redox Signal. 16, 950–964.Keywords
This publication has 161 references indexed in Scilit:
- Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationshipsExperimental Neurology, 2009
- Mitochondrial Gene Therapy Augments Mitochondrial Physiology in a Parkinson's Disease Cell ModelHuman Gene Therapy, 2009
- The Alzheimer's disease mitochondrial cascade hypothesis: An updateExperimental Neurology, 2009
- Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesisBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- The cybrid model of sporadic Parkinson's diseaseExperimental Neurology, 2009
- Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissuesBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- Complex I deficiency in Parkinson's disease frontal cortexBrain Research, 2008
- An enhanced MITOMAP with a global mtDNA mutational phylogenyNucleic Acids Research, 2006
- Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's diseaseJournal of the Neurological Sciences, 2006
- Maternal inheritance of human mitochondrial DNA.Proceedings of the National Academy of Sciences, 1980