Abnormal glomerular basement membrane maturation impairs mesangial cell differentiation during murine postnatal nephrogenesis

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Abstract
Mesangial cell-glomerular basement membrane (GBM) connections play an important role in maintaining the structural integrity of the glomerular tuft. However, information remains scarce about how GBM maturation affects the formation of these connections during glomerular development. Here, we show that abnormal GBM maturation due to tensin 2 deficiency affects mesangial cell differentiation by impairing mesangial cell-GBM connections during postnatal glomerulogenesis.
Funding Information
  • Japan Society for the Promotion of Science (19H04030)
  • National Institute of Biomedical Innovation, Health and Nutrition

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