Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells
- 3 October 2018
- journal article
- review article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 64 (1) , 25-38
Abstract
Acute pancreatitis is a human disease with multiple causes that leads to autodigestion of the pancreas. There is sufficient evidence to support the key role of sustained increase in cytosolic calcium concentrations in the early pathogenesis of the disease. To clarify the mechanism of maintaining calcium homeostasis in the cell and pathological processes caused by calcium overload would help to research directly targeted therapeutic agents. We will specifically review the following: intracellular calcium homeostasis and regulation, the occurrence of calcium overload in acinar cells, the role of calcium overload in the pathogenesis of AP, the treatment strategy proposed for calcium overload.Keywords
This publication has 110 references indexed in Scilit:
- A Novel Role for Bcl-2 in Regulation of Cellular Calcium ExtrusionCurrent Biology, 2012
- InsP3 receptors and Orai channels in pancreatic acinar cells: co-localization and its consequencesBiochemical Journal, 2011
- Activation of store-operated ICRAC by hydrogen peroxideCell Calcium, 2010
- NCLX is an essential component of mitochondrial Na+/Ca2+exchangeProceedings of the National Academy of Sciences, 2009
- Deletion of TRPC3 in Mice Reduces Store-Operated Ca2+ Influx and the Severity of Acute PancreatitisGastroenterology, 2009
- Pancreatic protease activation by alcohol metabolite depends on Ca 2+ release via acid store IP 3 receptorsProceedings of the National Academy of Sciences, 2009
- The Type 2 Inositol (1,4,5)-Trisphosphate (InsP3) Receptor Determines the Sensitivity of InsP3-induced Ca2+ Release to ATP in Pancreatic Acinar CellsJournal of Biological Chemistry, 2008
- Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseasesFree Radical Biology and Medicine, 2008
- Molecular basis of the CRAC channelCell Calcium, 2007
- STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ InfluxCurrent Biology, 2005