No impact of passive smoke on the somatic profile of lung cancers in never-smokers

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Abstract
EGFRandHER2mutations andALKrearrangement are known to be related to lung cancer in never-smokers, whileKRAS,BRAFandPIK3CAmutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed to passive smoke exhibit a “smoker-like” somatic profile compared with unexposed never-smokers.Passive smoke exposure was assessed in the French BioCAST/IFCT-1002 never-smoker lung cancer cohort and routine molecular profiles analyses were compiled.Of the 384 patients recruited into BioCAST, 319 were tested for at least one biomarker and provided data relating to passive smoking. Overall, 219 (66%) reported having been exposed to passive smoking. No significant difference was observed between mutation frequency and passive smoke exposure (EGFRmutation: 46% in never exposedversus41% in ever exposed;KRAS: 7%versus7%;ALK: 13%versus11%;HER2: 4%versus5%;BRAF: 6%versus5%;PIK3CA: 4%versus2%). We observed a nonsignificant trend for a negative association betweenEGFRmutation and cumulative duration of passive smoke exposure. No association was found for other biomarkers.There is no clear association between passive smoke exposure and somatic profile in lifelong, never-smoker lung cancer.
Funding Information
  • Eli Lilly and Company
  • Pfizer
  • Boehringer Ingelheim
  • AstraZeneca
  • Roche

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