Early Sepsis-Associated Acute Kidney Injury and Obesity

Authors:
  • KIKorean Sepsis Alliance Investigators
    Korean Sepsis Alliance Investigators
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Abstract
The prevalence of obesity is rising in intensive care units (ICUs) worldwide, and studies have reported that up to 20% of patients admitted to the ICU have obesity.1-3 Obesity is associated with numerous comorbidities, including diabetes, obstructive sleep apnea, and chronic kidney disease (CKD).4,5 Adipocytes contribute to the release of various adipokines,6 and this excess secretion of cytokines may lead to a low-grade systemic inflammatory state.4,7 In addition, elevated levels of free fatty acids and lipid intermediates contribute to insulin resistance, and chronic overactivity of the sympathetic nervous system can manifest as hypertension, leading to the development of metabolic derangements and comorbid diseases, such as congestive heart failure and stroke.4

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