wblE2transcription factor inStreptomyces griseusS4‐7 plays an important role in plant protection

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Abstract
Streptomyces griseusS4‐7 was originally isolated from the strawberry rhizosphere as a microbial agent responsible for Fusarium wilt suppressive soils.S. griseusS4‐7 shows specific and pronounced antifungal activity againstFusarium oxysporumf. sp.fragariae. In theStreptomycesgenus, thewhitranscription factors are regulators of sporulation, cell differentiation, septation, and secondary metabolites production.wblE2function as a regulator has emerged as a new group inwhitranscription factors. In this study, we reveal the involvement of thewblE2transcription factor in the plant‐protection byS. griseusS4‐7. We generated ΔwblE, ΔwblE2, ΔwhiH, and ΔwhmDgene knock‐out mutants, which showed less antifungal activity both in vitro andin planta. Among the mutants,wblE2 mutant failed to protect the strawberry against the Fusarium wilt pathogen. Transcriptome analyses revealed major differences in the regulation of phenylalanine metabolism, polyketide and siderophore biosynthesis between the S4‐7 and thewblE2 mutant. The results contribute to our understanding of the role of streptomyceteswblE2genes in a natural disease suppressing system.
Funding Information
  • Next-Generation BioGreen 21 Progra (PJ011800)

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