Supplementary Figure 1 from Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations

Authors:
  • MTMichael T. Tetzlaff
    Michael T. Tetzlaff
  • JCJonathan L. Curry
    Jonathan L. Curry
  • OSOded Sagiv
    Oded Sagiv
  • TKThomas L. Kandl
    Thomas L. Kandl
  • BPBo Peng
    Bo Peng
  • DBDiana Bell
    Diana Bell
  • CHCourtney W. Hudgens
    Courtney W. Hudgens
  • DIDoina Ivan
    Doina Ivan
  • TKTae-Boom Kim
    Tae-Boom Kim
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Abstract
Supplemental Figure 1. Representative images of nuclear grade. Histopathologic grade was defined according to the nuclear morphology and cytoplasmic evidence of sebaceous differentiation comprising the predominance (>50%) of the tumor cells. (A) High grade tumors exhibited enlarged irregular nuclei with high nuclear:cytoplasmic ratio and only focal evidence of sebaceous differentiation (intracytoplasmic vacuoles indenting the nucleus; H&E, 200x). (B) Intermediate grade tumors exhibited similar enlarged nuclei but with lower nuclear:cytoplasmic ratio and more obvious evidence of sebaceous differentiation (H&E, 200x). (C) Well-differentiated tumors showed only slightly enlarged nuclei and frank evidence of sebaceous differentiation (H&E, 200x).