Regional Brain Metabolic Changes in Patients With Major Depression Treated With Either Paroxetine or Interpersonal Therapy

Authors:
  • SSSanjaya Saxena
    Sanjaya Saxena
  • PSPaula Stoessel
    Paula Stoessel
  • LGLaurie A. Gillies
    Laurie A. Gillies
  • LFLynn A. Fairbanks
    Lynn A. Fairbanks
  • SAShervin Alborzian
    Shervin Alborzian
  • MPMichael E. Phelps
    Michael E. Phelps
  • SHSung-Cheng Huang
    Sung-Cheng Huang
  • HWHsiao-Ming Wu
    Hsiao-Ming Wu
  • MHMatthew L. Ho
    Matthew L. Ho
  • MHMai K. Ho
    Mai K. Ho
  • SAScott C. Au
    Scott C. Au
Open Access
Publisher website
Google Scholar
Abstract
THE REGIONS most commonly found to be abnormal in functional brain imaging studies of major depressive disorder (MDD) are the prefrontal cortex (PFC), anterior cingulate gyrus (AC), and temporal lobe (TEMP).1-4 Because there are reports of both increased and decreased activity in these structures in MDD, researchers have suspected that subregions of these structures have differentially altered function in MDD. Specifically, it has been hypothesized that dorsal brain structures (eg, dorsolateral prefrontal cortex [DLPFC]) have decreased activity,1-3,5-7 while ventral structures (eg, ventrolateral prefrontal cortex [VLPFC] and ventral AC) have increased activity in the symptomatic depressed state.3,5,6,8

This publication has 37 references indexed in Scilit: