Defective medium-chain fatty acid β-oxidation in the liver alters the fat preference and induces hepatic steatosis and glucose intolerance

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Abstract
Medium-chain triglycerides (MCTs) exert antiobesity effects; however, whether these antiobesity effects are observed when the MCT/long-chain triglyceride intake is altered using a high-fat diet (30 kcal% fat) remains unclear. This study found that impaired medium-chain fatty acid metabolism in the liver reduced MCT preference, without altering the total fat intake, resulting in metabolic dysfunction. Therefore, increasing the MCT ratio in dietary fats possibly reduces the risk of obesity.
Funding Information
  • MEXT | Japan Society for the Promotion of Science (20H00412)
  • Food Science Institute Foundation
  • Novartis Pharma Foundation
  • Japan Foundation for Applied Enzymology
  • Uehara Memorial Foundation
  • Foundation for Dietary Scientific Research
  • MEXT | JST | Support for Pioneering Research Initiated by the Next Generation (JPMJSP2110)
  • Japan Science Society

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