Effect of Dexmedetomidine, a Selective and Potent ??2-Agonist, on Cerebral Blood Flow and Oxygen Consumption During Halothane Anesthesia in Dogs

Authors:
  • MFMarianne Forsman
    Marianne Forsman
  • OROle K. Roald
    Ole K. Roald
  • MHMona S. Heier
    Mona S. Heier
  • PSPetter A. Steen
    Petter A. Steen
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Abstract
Lothane by 90%. During 0.9% halothane anesthesia dexmedetomidine caused a significant reduction in CBF without influencing the metabolic rate for oxygen. Reducing the halothane concentration to 0.1% caused no further change in CBF, but increased the metabolic rate for oxygen 19%. The cerebral vasoconstrictive effect, combined with the 90% reduction in MAC for halothane, indicates that dexmedetomidine might be a useful adjunct to inhalation anesthetics during neurosurgery in situations where an increase in CBF should be avoided. Address correspondence to Dr. Karlsson, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway. Supported by grants from the Norwegian Research Council for Science and the Humanities, and Anders Jahre's Fund for the Promotion of Science. The authors greatly appreciate the excellent technical assistance of Unni Lie-Henriksen, Bjerg Austber, and Vigdis Braathen. They also want to thank Dr. A. Kallio, Farmos Group Ltd., Turku, Finland, for providing them with dexmedetomidine and useful information. Accepted for publication April 5, 1990. © 1990 International Anesthesia Research Society...

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