Figure S4 from Improving Intracellular Delivery of an Antibody–Drug Conjugate Targeting Carcinoembryonic Antigen Increases Efficacy at Clinically Relevant Doses In Vivo

Authors:

Ian Nessler
Ian Nessler
BRBaron Rubahamya
Baron Rubahamya
AKAnna Kopp
Anna Kopp
SHScott Hofsess
Scott Hofsess
TCThomas M. Cardillo
Thomas M. Cardillo
NSNalini Sathyanarayan
Nalini Sathyanarayan
JDJennifer Donnell
Jennifer Donnell
SGSerengulam V. Govindan
Serengulam V. Govindan
Greg M. Thurber
Greg M. Thurber

Open Access

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4 March 2024

other
Published by American Association for Cancer Research (AACR)

DOI:10.1158/1535-7163.25338061.v1

Abstract

HiSep XAb-SN-38. HPLC detection at 360 nm, SN-38 absorbance region, with 98.7% associated with the peak corresponding to the antibody. Peak at 8.123 mm is due to unremoved SN-38.

Keywords

BIOLOGICAL AGENTS & THERAPIES
ANTIBODY-DRUG CONJUGATES
ENGINEERING
PHARMACOLOGY
PHARMACOKINETICS AND PHARMACODYNAMICS