Polymeric Micellar Formulation Enhances Antimicrobial and Anticancer Properties of Salinomycin

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Abstract
Salinomycin (SAL) is a polyether compound that exhibits strong antimicrobial as well as anticancer activity. Nanomedicine has been at the forefront of drug delivery research with the aim of increasing the efficacy, specificity and reduce toxicity of drugs. There is an intersection between infection and cancer, and cancer patients are prone to bacterial infections. In this study, polymeric micelles were prepared using Pluronic® F127 (PM) to encapsulate SAL (PM_SAL) with the view of enhancing antimicrobial and anticancer activity.
Funding Information
  • Fundação para a Ciência e a Tecnologia (ENMed/0065/2016)
  • Fundação para a Ciência e a Tecnologia (ENMed/0009/2015)
  • iMed.ULisboa (UID/DTP/04138/2013)
  • SimInhale (COST Action MP1404)

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