Accessing Heterobiaryls through Transition-Metal-Free C–H Functionalization
- 13 February 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 83 (6) , 3236-3244
Abstract
Herein we report a transition metal-free synthetic protocol for heterobiaryls, one of the most important pharmacophores in modern drug industry, employing a new multidonor phenalenyl (PLY) based ligand. The current procedure offers wide substrate scope (24 examples) with a low-catalyst loading resulting in excellent product yield (upto 95%). The reaction mechanism involves a single electron transfer (SET) from a phenalenyl based radical to generate reactive heteroaryl radical. To establish the mechanism, we have isolated the catalytically active SET initiator and characterized by magnetic study.Keywords
Funding Information
- Council of Scientific and Industrial Research (01(2779/14/EMR-II)
- University Grants Commission
- Anusandhan National Research Foundation (YSS/2014/000877, PDF/2016/000213)
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