Active regulation of protein coronas for enhancing the in vivo biodistribution and metabolism of nanoparticles
- 20 July 2024
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Inorganic Chemistry Frontiers
- Vol. 11 (17) , 5741-5752
Abstract
Pre-attaching nanobodies to nanoparticle surface with a PEG spacer offers a strategy to actively regulate protein corona in quantity and composition, markedly impacts nanoparticle biodistribution and metabolism in vivo.Keywords
Funding Information
- National Basic Research Program of China (2020YFA0710700)
- National Natural Science Foundation of China (52021002, 32101121, 22177109, 22377116)
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