Hypercalcemia and vitamin d metabolism in Hodgkin's disease. Is there an underlying immunoregulatory relationship?
Authors:
Abstract
Hypercalcemia is not common in Hodgkin''s disease, but in reported cases is often unassociated with bone involvement. A case is presented demonstrating a mechanism involving elevated levels of 1,25-dihydroxy vitamin D3 (calcitriol). Similar cases in the literature are reviewed. Data implicating calcitriol as a hematolymphoid regulatory hormone are discussed as they may relate to lymphomas, leukemias, and paraneoplastic lymphocyte and monocyte/macrophage activity.Keywords
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