The metabolome of an E. coli CRISPRi library identifies benefits of minimal metabolite levels and targets for engineering
Open Access
- 5 March 2026
- journal article
- Published by Elsevier in Cell Systems
- Vol. 17 (4) , 101518
Abstract
No abstract availableKeywords
Funding Information
- H2020 European Research Council (715650)
- Deutsche Forschungsgemeinschaft (EXC2124)
- European Research Council
- Deutsches Zentrum für Infektionsforschung (TTU06.716)
This publication has 53 references indexed in Scilit:
- Systematic analysis of in-source modifications of primary metabolites during flow-injection time-of-flight mass spectrometryAnalytical Biochemistry, 2023
- Homeostasis of the biosynthetic E. coli metabolomeiScience, 2022
- Hybrid Chemoenzymatic Synthesis of C7‐Sugars for Molecular Evidence of in vivo Shikimate Pathway InhibitionChemBioChem, 2022
- Multi-omics Analysis of CRISPRi-Knockdowns Identifies Mechanisms that Buffer Decreases of Enzymes in E. coli MetabolismCell Systems, 2021
- Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilisCell Systems, 2020
- Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic ActivityCell Reports, 2017
- Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State DataCell Systems, 2015
- One hundred years of Michaelis–Menten kineticsPerspectives in Science, 2015
- Determining Microbial Products and Identifying Molecular Targets in the Human MicrobiomeCell Metabolism, 2014
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene ExpressionCell, 2013