Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans
Open Access
- 10 September 2022
- journal article
- research article
- Published by MDPI AG in Marine Drugs
- Vol. 20 (9) , 574
Abstract
Five new cembranes, named sarcoeleganolides C–G (1–5), along with three known analogs (6–8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 μM.Keywords
Funding Information
- National Natural Science Foundation of China (41876161, U2006204, 81991522)
This publication has 35 references indexed in Scilit:
- Copper toxicology, oxidative stress and inflammation using zebrafish as experimental modelJournal of Applied Toxicology, 2016
- Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine InvertebratesMarine Drugs, 2015
- Cytotoxic Biscembranoids from the Soft Coral Sarcophyton pauciplicatumChemical and Pharmaceutical Bulletin, 2015
- Capnosane-type cembranoids from the soft coral Sarcophyton trocheliophorum with antibacterial effectsTetrahedron, 2014
- Theoretical study on the structures and electronic properties of oligo(p-phenylenevinylene) carboxylic acid and its derivatives: effects of spacer and anchor groupsTheoretical Chemistry Accounts, 2012
- New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelaeMarine Drugs, 2012
- Assigning Stereochemistry to Single Diastereoisomers by GIAO NMR Calculation: The DP4 ProbabilityJournal of the American Chemical Society, 2010
- New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.Electronic supplementary information (ESI) available: Mosher results for compound 3. See http://www.rsc.org/suppdata/ob/b2/b210039h/Organic & Biomolecular Chemistry, 2003
- New Cembranoid Diterpenes from the Soft Coral Sarcophyton ehrenbergiJournal of Natural Products, 1998
- Three New Diterpenes from the Marine Soft Coral Lobophytum crassumJournal of Natural Products, 1998