Determination of adaptability to dental prostheses in conditions of physiological secretion of the saliva

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Abstract
Presence of the prosthetic dentures in the human oral cavity for a long time has an effect on the oral fluid and the condition of the oral mucosa. In return, it is not always objective to determine the adaptive ability of each individual. All of it is also burdened by the difference between the prosthetic structures and the materials used. The aim of the study is to determine the effect of orthopedic structures of dental prostheses on the tissues and organs of the maxillofacial region by the expression of biomarkers of oral fluid. Material and methods. The study group included 65 people without diseases of the oral system as a reference range group, and 80 patients without a general somatic problems but who had not previously received dental Prosthetic treatment and in need of it, as a clinical study group. To determine the effect of orthopedic structures on the tissues and organs of the maxillofacial region, 80 structures of orthopedic prostheses were made for patients. With a partial defect in the dentition, 38 bridges, 18 partially removable plate prostheses and 9 clasp prostheses were installed, as well as 15 complete removable plate prostheses in the absence of teeth. To identify the adaptive properties and the effect of orthopedic structures on the tissues and organs of the maxillofacial region, a clinical and dental examination and determination of the expression of biomarkers of the oral fluid by immunological methods were used enzyme immunoassay. To identify the informative value of the diagnostic test, we used the definition of diagnostic sensitivity (Se), as the ability to detect a disease in people who actually have this disease. Results. The adaptive ability to prosthetic structures of the patients of the clinical comparison group was manifested by an increase in the expression of oral fluid biomarkers MMP-2, MMP-8 and TIMP-2 in the early adaptation period and a decrease of MMP-8 after 3 months of operation (p<0.05). Conclusions. The data obtained indicate the possibility of determining and evaluating the adaptive ability of tissues and organs of the maxillofacial region to orthopedic prosthesis structures in patients, which is manifested by the reaction of biomarkers in the oral fluid.

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