Assessment of SARS-CoV-2 Seropositivity During the First and Second Viral Waves in 2020 and 2021 Among Canadian Adults

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Abstract
As of December 15, 2021, Canada had reported more than 1.8 million cases of SARS-CoV-2 infection and approximately 30 000 deaths associated with COVID-19. Slightly fewer than 60% of cases and more than 80% of deaths occurred during the combined first (April to July 2020) and second (October 2020 to March 2021) viral waves, when the original SARS-CoV-2 was the predominant strain in circulation.1 Before the onset of the viral wave caused by the Omicron variant, which began on December 15, 2021, reported case rates in Canada (Figure 1) had been approximately one-third of those in the US and one-half of those in the United Kingdom.2 At the population level, the incidence of infection during each wave, the factors associated with infection, the levels and factors associated with asymptomatic infection, and the durability of antibody responses against infection remain uncertain.

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