Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma
Authors:
- 22 January 2010
- journal article
- Published by Taylor & Francis in Immunopharmacology and Immunotoxicology
- Vol. 32 (3) , 364-370
Abstract
Many flavonoids were demonstrated to posses the antiallergic effect. Here we detected whether apigenin, a flavonoid, can attenuate allergen-induced airway inflammation and what is the possible mechanism in a murine model of asthma. Apigenin decreased the degree of the inflammatory cell infiltration, airway hyperresponsiveness, and total immunoglobulin E levels compared with the ovalbumin group. In addition, apigenin triggered the switching of the immune response to allergens toward a T-helper type 1 (Th1) profile. Our data clearly demonstrated that apigenin exhibits an anti-inflammatory activity in a murine asthma model, and can switch the immune response to allergens toward the Th1 profile.Keywords
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