Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple-negative breast cancer
- 22 September 2025
- journal article
- Published by Elsevier in European Journal of Medicinal Chemistry
- Vol. 300, 118189
Abstract
No abstract availableKeywords
Funding Information
- National Natural Science Foundation of China (2024ZD0520405)
- National Natural Science Foundation of China (2024ZD0520400)
- National Natural Science Foundation of China (82373769)
- Fundamental Research Funds for the Central Universities (2632024TD08)
- National Science and Technology Major Project (2024ZD0520405)
- National Science and Technology Major Project (2024ZD0520400)
This publication has 49 references indexed in Scilit:
- G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosisBiochemical Pharmacology, 2024
- Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophagesBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019
- Effects of intracellular iron overload on cell death and identification of potent cell death inhibitorsBiochemical and Biophysical Research Communications, 2018
- Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and DiseaseCell, 2017
- Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysisBiochemical and Biophysical Research Communications, 2017
- Regulation of Ferroptotic Cancer Cell Death by GPX4Cell, 2014
- Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog SignalingAngewandte Chemie International Edition, 2013
- Biology‐Oriented Synthesis of a Tetrahydroisoquinoline‐Based Compound Collection Targeting Microtubule PolymerizationChemBioChem, 2013
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell DeathCell, 2012
- Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell DeathCell Metabolism, 2008