Electrochemical Decarboxylation of Hydroxyproline: A Simple Three-Step Conversion of (2S,4R)-4-Hydroxyproline to (R)-γ-Amino-β-hydroxybutanoic Acid (GABOB)

Authors:
  • PRPhilippe Renaud
    Philippe Renaud
  • DSDieter Seebach
    Dieter Seebach
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Abstract
A high yield conversion on preparative scale of (2S,4R)-N-acetyl-4-hydroxyproline (1) to (R)-GABOB (4) is reported. The key step of the synthesis is the electrochemical oxidative decarboxylation of 1.