Differential Regulatory Analysis Based on Coexpression Network in Cancer Research

Authors:
Open Access
Publisher website
Google Scholar
Abstract
With rapid development of high-throughput techniques and accumulation of big transcriptomic data, plenty of computational methods and algorithms such as differential analysis and network analysis have been proposed to explore genome-wide gene expression characteristics. These efforts are aiming to transform underlying genomic information into valuable knowledges in biological and medical research fields. Recently, tremendous integrative research methods are dedicated to interpret the development and progress of neoplastic diseases, whereas differential regulatory analysis (DRA) based on gene coexpression network (GCN) increasingly plays a robust complement to regular differential expression analysis in revealing regulatory functions of cancer related genes such as evading growth suppressors and resisting cell death. Differential regulatory analysis based on GCN is prospective and shows its essential role in discovering the system properties of carcinogenesis features. Here we briefly review the paradigm of differential regulatory analysis based on GCN. We also focus on the applications of differential regulatory analysis based on GCN in cancer research and point out that DRA is necessary and extraordinary to reveal underlying molecular mechanism in large-scale carcinogenesis studies.
Funding Information
  • National Basic Research Program of China (2012YQ03026108, 31501077, 2012CB316501, 2013CB910801, 14DZ1951300, 14DZ2252000)
  • National Natural Science Foundation of China (2012YQ03026108, 31501077, 2012CB316501, 2013CB910801, 14DZ1951300, 14DZ2252000)
  • National “973” Key Basic Research Development Program (2012YQ03026108, 31501077, 2012CB316501, 2013CB910801, 14DZ1951300, 14DZ2252000)
  • National “973” Key Basic Research Development Program (2012YQ03026108, 31501077, 2012CB316501, 2013CB910801, 14DZ1951300, 14DZ2252000)
  • Fundamental Research Program of Shanghai Municipal Commission of Science and Technology (2012YQ03026108, 31501077, 2012CB316501, 2013CB910801, 14DZ1951300, 14DZ2252000)
  • Fundamental Research Program of Shanghai Municipal Commission of Science and Technology (2012YQ03026108, 31501077, 2012CB316501, 2013CB910801, 14DZ1951300, 14DZ2252000)

This publication has 66 references indexed in Scilit: