Δ‐Aminolevulinatedehydrase: synteny with ABO‐AK1‐ORM (and assignment to chromosome 9)

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Abstract
A material comprising 846 normal familes from the Copenhagen [Denmark] area (family no. 604-1505) was tested for .delta.-aminolevulinatedehydrogenase. Among the 1697 unrelated individuals (parents), the gene frequencies were 0.9378 for ALADH*1 and 0.0622 for ALADH*2. The distribution of phenotypes and the segregation ratios did not deviate significantly from the expected values. Linkage analysis was carried for markers on chromosome 9, following a hint of ALADH-ORM linkage in part of the material. This was confirmed, and the most likely sequence, as judged from male .cxa..theta. [95% confidence limits] values, was ABO-AK1-ALADH-ORM. The .cxa..theta. and .cxa.z [lod score] values were as follows: ABO-AK1 (.cxa..theta. = 0.13, .cxa.z =6.27), ABO-ALADH (.cxa..theta. = 0.21, .cxa.z = 5.38), ABO-ORM (.cxa..theta. = 0.27, .cxa..zeta. = 5.06), AK1-ORM (.cxa..theta. = 0.17, .cxa.z = 1.63), ALADH-ORM (.cxa..theta. = 0.13, .cxa.z = 705) and AK1-ALADH (.cxa..theta. = 0.11, .cxa.z = 245).

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