Porphyrin–Lipid Stabilized Gold Nanoparticles for Surface Enhanced Raman Scattering Based Imaging
- 16 August 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 23 (9) , 1726-1730
Abstract
A porphyrin–phospholipid conjugate with quenched fluorescence was utilized to serve as both the Raman dye and a stabilizing, biocompatible surface coating agent on gold nanoparticles. Through simple synthesis and validation with spectroscopy and confocal microscopy, we show that this porphyrin–lipid stabilized AuNP is a novel SERS probe capable of cellular imaging. To date, this is the first use of porphyrin as a Raman reporter molecule for SERS based imaging.Keywords
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