Epoetin delta is effective for the management of anaemia associated with chronic kidney disease

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Abstract
Objective: To demonstrate the efficacy and safety of epoetin delta for the treatment of anaemia in dialysis patients with chronic kidney disease (CKD).Research design and methods: This was a 12‐week, randomized, double-blind, active-comparator study. CKD patients who were naïve to epoetin treatment and had haemoglobin < 10 g/dL were randomized to epoetin delta 15, 50, 150, or 300 IU/kg or epoetin alfa 50 IU/kg. Patients initially entered a correction phase until they recorded haemoglobin of ≥ 11.5 g/dL for two consecutive weekly measurements or one haemoglobin measurement of ≥ 13 g/dL (correction success). A maintenance phase followed where the dose was adjusted to maintain haemoglobin ≥ 10.5 g/dL. Maintenance success was defined as haemoglobin > 10.5 g/dL at Week 12. Total success was defined as achieving maintenance and correction success.Main outcome measures: The primary objective was to demonstrate that the proportion of patients achieving total success was greater in the pooled 150 IU/kg and...

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