Selective synthesis and biological activity of triazine-porphyrins as potential anti-cancer agents
Authors:
- 1 February 2010
- journal article
- research article
- Published by World Scientific Pub Co Pte Ltd in Journal of Porphyrins and Phthalocyanines
- Vol. 14 (02) , 123-127
Abstract
Ten new triazine-porphyrin derivatives were synthesized using a simple one-pot procedure from the reaction of tetraphenylporphyrin bearing a hydroxyl group with 2,4,6-trichloro-1,3,5-triazine, and then with amines or alcohols. The structures of the products were characterized by 1H NMR, LC/MS, UV-vis and elemental analysis. The cytotoxic activity of the triazine-porphyrin derivatives was evaluated in vitro against MCF-7 cell. All new compounds showed similar activity against MCF-7 cells in the absence of light when compared to 5-fluorouracil and hematoporphyrin.Keywords
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