Phosphate Ester Hydrolysis: Metal Complexes As Purple Acid Phosphatase and Phosphotriesterase Analogues
Authors:
- 18 June 2009
- journal article
- review article
- Published by Wiley in European Journal of Inorganic Chemistry
- Vol. 2009 (19) , 2745-2758
Abstract
This microreview describes the structures and properties of a number of bimetallic complexes designed as both structural and functional mimics of the active sites of some specific metallohydrolase enzymes. The metalloenzymes in question include the predominantly monoesterase‐activity‐displaying purple acid phosphatase (PAP) and di‐ and triesterase enzymes, which have significant roles in the bioremedial hydrolysis of organophosphate pesticides and nerve gases. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)Keywords
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