Decarboxylative Synthesis of Functionalized Oxindoles via An Iron‐Initiated Radical Chain Process and Application in Constructing Diverse Fused‐Indoline Heterocycles
- 20 October 2017
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 360 (1) , 93-99
Abstract
Rapid construction of diverse fused‐indoline−heterocycle (FIH) frameworks including high‐value pyrroloindolines, furoindolines and thienoindolines in a two‐step sequence has been described. The key to success hinges on the adoption of peresters as α‐heteroatom alkyl radical precusors, which can smoothly react with N‐arylacrylamides via a radical chain process initiated by inexpensive FeCl2⋅4H2O to afford the functionalized oxindoles, the key intermediates to FIH skeletons. The approach features operationally‐simplicity, broad substrates scope and mild conditions. magnified imageKeywords
Funding Information
- National Natural Science Foundation of China (21272024)
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