Studies on new antiplatelet agents, WS-30581 A and B.

Authors:
  • KUKazuyoshi Umehara
    Kazuyoshi Umehara
  • KYKeizo Yoshida
    Keizo Yoshida
  • MOMasanori Okamoto
    Masanori Okamoto
  • MIMorita Iwami
    Morita Iwami
  • HTHirokazu Tanaka
    Hirokazu Tanaka
  • MKMasanobu Kohsaka
    Masanobu Kohsaka
  • HIHiroshi Imanaka
    Hiroshi Imanaka
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Abstract
WS-30581 A and B are antiplatelet agents produced by a strain of Streptoverticillium waksmanii. The compounds were purified by solvent extraction and column chromatography, and identified as new pimprinine analogs on the basis of their physico-chemical properties. The producing organism produced pimprinine along with these compounds. Pimprinine and the two new analogs have potent inhibitory effects on platelet aggregation.