RELEASE OF NEWLY SYNTHESIZED DOPAMINE FROM DOPAMINE-CONTAINING TERMINALS IN THE STRIATUM OF THE RAT
Authors:
- 1 March 1969
- journal article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 62 (3) , 741-748
Abstract
The extraneuronal spontaneous efflux of 3 H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro , by collecting the 3 H amine in superfusates of isolated striatum of the rat previously incubated with 3 H-tyrosine. The 3 H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) markedly increased the release of 3 H-dopamine. This effect was also observed with substances normally contained in some striatal neurons: acetylcholine and 5-hydroxytryptamine.Keywords
This publication has 17 references indexed in Scilit:
- Histochemical studies on the effect of (+)-amphetamine, drugs of the imipramine group and tryptamine on central catecholamine and 5-hydroxytryptamine neurons after intraventricular injection of catecholamines and 5-hydroxytryptamineEuropean Journal of Pharmacology, 1968
- SELECTIVE RELEASE OF NEWLY SYNTHESIZED NOREPINEPHRINE FROM THE CAT SPLEEN DURING SYMPATHETIC NERVE STIMULATIONThe Journal of Pharmacology and Experimental Therapeutics, 1968
- THE RATE OF NOREPINEPHRINE SYNTHESIS MEASURED IN VIVO DURING SHORT INTERVALS; INFLUENCE OF ADRENERGIC NERVE IMPULSE ACTIVITYThe Journal of Pharmacology and Experimental Therapeutics, 1968
- Release by tubocurarine of dopamine and homovanillic acid from the superfused caudate nucleusThe Journal of Physiology, 1968
- A MUSCARINIC MECHANISM INHIBITING THE RELEASE OF NORADRENALINE FROM PERIPHERAL ADRENERGIC NERVE FIBRES BY NICOTINIC AGENTSBritish Journal of Pharmacology, 1968
- Oxotremorine and central monoamine neuronsLife Sciences, 1967
- THE ESTIMATION OF SMALL QUANTITIES OF 3,4‐DIHYDROXYPHENYLETHYLAMINE IN TISSUESBritish Journal of Pharmacology and Chemotherapy, 1965
- METABOLISM OF [3H]NOREPINEPHRINE IN THE RAT BRAINJournal of Neurochemistry, 1965
- The effects of cocaine, amphetamine and some amphetamine-like compounds on the in vivo levels of noradrenaline and dopamine in the rat brainBiochemical Pharmacology, 1964
- The release of acetylcholine and of 3‐hydroxytyramine from the caudate nucleusThe Journal of Physiology, 1964