Effects of pomegranate juice on the sexual behavior, fertility and protective activity against aluminum exposure in male mice

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Abstract
This experiment aimed to determine how pomegranate juice (PJ) responds to oxidative stress induced by aluminum in male mice. A total of thirty-six male mice were separated into six groups. The first group (control group) received tap water. Groups two and three were given 20% and 40% PJ, respectively. Group four received 400 mg Al/kg, while groups five and six were given Al + 20% PJ and Al + 40% PJ, respectively. After the oral administration period, the sexual behavior of the mice was recorded. Blood was collected from the heart to measure testosterone concentration. After the animals were sacrificed, the reproductive organs were weighed, and the epididymis and testis were used for further evaluations. Our findings showed that Al decreased the body and organs weights, sexual behavior, sperm count, normal sperm, total and progressive sperm motility, testosterone level, and epithelial diameters of the seminiferous tubes. In addition, the PJ reduced these effects and minimized the aluminum toxicity in male mice. In conclusion, PJ protects against aluminum exposure in male mice by ameliorating sexual behavior and fertility.

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