Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8+ T cells and dendritic cells
Open Access
- 27 June 2013
- journal article
- Published by American Society of Hematology in Blood
- Vol. 121 (26) , 5184-5191
Abstract
Key Points: Defects in perforin and related genes lead to abnormal T-cell activation and are associated with HLH. The physiological mechanism by which perforin protects from HLH involves CD8+ T-cell elimination of rare antigen-presenting dendritic cells.Keywords
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