Selegiline Is Ineffective in a Collaborative Double-blind, Placebo-Controlled Trial for Treatment of Amyotrophic Lateral Sclerosis
Authors:
- Peregrine L. MurphyPMPeregrine L. Murphy
- Beverly DiamondBDBeverly Diamond
- Vicki AppelVAVicki Appel
- Eugene C. LaiELEugene C. Lai
- David S. YoungerDYDavid S. Younger
- Stanley H. AppelSAStanley H. Appel
Open Access
- 1 January 1998
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 55 (1) , 93-96
Abstract
AMYOTROPHIC lateral sclerosis (ALS) is a progressive neuromuscular disease manifested as weakness and wasting of all skeletal muscles of the body, ending in death due to respiratory failure.1 The cause is unknown, but possibilities include oxidative damage,2,3 toxic effects of glutamate,4 deficiency of neurotrophic factors,5 chronic viral infection,6 and immunological attack against motor neurons.7 Another neurodegenerative disease, Parkinson disease, seems to progress slower when patients are treated with the monoamine oxidase-B (MAO-B) inhibitor selegiline hydrochloride (Eldepryl).8 To determine if similar effects could be seen in ALS, we performed a randomized, double-blind, placebo-controlled trial.Keywords
This publication has 13 references indexed in Scilit:
- Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival predictionBrain, 1995
- (-)Deprenyl increases activities of superoxide dismutase and catalase in certain brain regions in old male miceLife Sciences, 1994
- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisNature, 1993
- Serum Antibodies to L-Type Calcium Channels in Patients with Amyotrophic Lateral SclerosisNew England Journal of Medicine, 1992
- Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral SclerosisNew England Journal of Medicine, 1992
- Deprenyl suppresses the oxidant stress associated with increased dopamine turnoverAnnals of Neurology, 1989
- Pharmacokinetics and metabolism of selegilineActa Neurologica Scandinavica, 1989
- A Double-blind Study of the Effectiveness of Cyclosporine in Amyotrophic Lateral SclerosisArchives of Neurology, 1988
- A rating scale for amyotrophic lateral sclerosis: Description and preliminary experienceAnnals of Neurology, 1987
- A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer diseaseAnnals of Neurology, 1981