Identifying Patients for Intensive Blood Pressure Treatment Based on Cognitive Benefit
Authors:
- Lama GhaziLGLama Ghazi
- Jincheng ShenJSJincheng Shen
- Jian YingJYJian Ying
- Catherine G. DeringtonCDCatherine G. Derington
- Jordana B. CohenJCJordana B. Cohen
- Zachary A. MarcumZMZachary A. Marcum
- Jennifer S. HerrickJHJennifer S. Herrick
- Jordan B. KingJKJordan B. King
- Alfred K. CheungACAlfred K. Cheung
- Jeff D. WilliamsonJWJeff D. Williamson
- Nicholas M. PajewskiNPNicholas M. Pajewski
Open Access
- 1 May 2023
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Network Open
- Vol. 6 (5) , e2314443
Abstract
In the Systolic Blood Pressure Intervention Trial (SPRINT), intensive (systolic blood pressure [SBP] goal 1,2 While Williamson et al1 have previously shown that intensive treatment reduced the risk of MCI or probable dementia overall on average, the study did not address treatment effect heterogeneity and which populations derive the greatest absolute benefit for prioritization. As we have previously seen, the magnitude of absolute benefit from intensive treatment for CVD outcomes was greatest for those at highest baseline CVD risk, and this population should initially be targeted.3 As such, cognitive benefit from intensive vs standard SBP treatment may vary among patients.Keywords
This publication has 39 references indexed in Scilit:
- Risk Factors for the Progression of Mild Cognitive Impairment to DementiaClinics in Geriatric Medicine, 2013
- Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort studyThe Lancet, 2012
- Ascertaining dementia‐related outcomes for deceased or proxy‐dependent participants: an overview of the Women's Health Initiative Memory Study supplemental case ascertainment protocolInternational Journal of Geriatric Psychiatry, 2011
- On the C‐statistics for evaluating overall adequacy of risk prediction procedures with censored survival dataStatistics in Medicine, 2011
- Education and dementiaNeurology, 2007
- The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive ImpairmentJournal of the American Geriatrics Society, 2005
- Regularization and Variable Selection Via the Elastic NetJournal of the Royal Statistical Society Series B: Statistical Methodology, 2005
- Subgroup analyses in randomized trials: risks of subgroup-specific analyses;Journal of Clinical Epidemiology, 2004
- A Validation Study of the Dementia QuestionnaireArchives of Neurology, 1994
- Measurement of Functional Activities in Older Adults in the CommunityJournal of Gerontology, 1982