Immunoglobulin M Antibodies with Ten Combining Sites
Authors:
- 1 November 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3853) , 574-576
Abstract
Immunoglobulin M rabbit antibodies to a hapten are shown to have ten binding sites per molecule. The affinity for the specific hapten is approximately 100 times greater for one-half of the sites than for the other half. All sites are retained in the five 7S subunits produced by reduction and alkylation of the immunoglobulin M. Each of the 7S subunits of the IgM molecule apparently has one strong and one weak site.Keywords
This publication has 9 references indexed in Scilit:
- THE SUBUNITS IN RABBIT ANTI-FORSSMAN IGM ANTIBODYJournal of Experimental Medicine, 1968
- Papain Fragmentation of the Subunits of Human MacroglobulinThe Journal of Immunology, 1967
- Precipitin activity of rabbit macroglobulin antibodyImmunochemistry, 1966
- Characterization of a Human MacroglobulinJournal of Biological Chemistry, 1966
- Number of binding sites of rabbit macroglobulin antibody and its subunitsImmunochemistry, 1965
- Immunoadsorbents with high capacityImmunochemistry, 1965
- Quantitative Determination of Serum Immunoglobulins in Antibody-Agar PlatesThe Journal of Immunology, 1965
- Nature of the Combining Site of Antibody against a Hapten Bearing a Positive Charge1Journal of the American Chemical Society, 1960
- Heterogeneity and Average Combining Constants of Antibodies from Individual RabbitsThe Journal of Immunology, 1958