Synthesis and Antitumor Activity of Novel α-Substituted Aminomethylphosphonates
Authors:
- 1 April 1994
- journal article
- research article
- Published by Taylor & Francis in Phosphorus, Sulfur, and Silicon and the Related Elements
- Vol. 89 (1-4) , 97-104
Abstract
Two series of novel α-substituted aminomethyl phosphonates (1) and (2) have been synthesized and the reaction conditions are discussed. All the products have been confirmed by 1H NMR, IR spectra and elemental analysis, and x-ray diffraction. The bioassay showed that some of the compounds inhibit the growth of the leukemia L1210 cell in vitro.Keywords
This publication has 2 references indexed in Scilit:
- OPTICALLY ACTIVE 1-AMINOALKYLPHOSPHONIC ACIDSPhosphorus and Sulfur and the Related Elements, 1987
- Phosphinic acid dipeptide analogs: potent, slow-binding inhibitors of aspartic peptidasesJournal of the American Chemical Society, 1984