Abstract
The article highlights the results of an analysis of literary sources, emphasizing the importance of studying naturally occurring infections, particularly dangerous ones, caused by pathogens belonging to the Flaviviridae family, in relation to human health and veterinary medicine. This family is divided into four genera: Flavivirus, Pestivirus, Hepacivirus, and Pegivirus. The Flavivirus genus (Orthoflavivirus), the most significant for humans, belongs to the arbovirus family, which is transmitted by arthropod vectors, such as mosquitoes and ticks. Vectors become infected when they feed on the blood of infected reservoir animals. Afterward, they are capable of transmitting the virus to humans. Transmission of pathogens through unprocessed milk and organ transplantation is also possible. The viruses of yellow fever, Japanese encephalitis, tick-borne encephalitis, Omsk hemorrhagic fever, dengue, Zika, West Nile, Murray Valley encephalitis, and Pyasanu encephalitis, as well as Kiasanur forest disease and Alhumra hemorrhagic fever, are of epidemiological significance

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