Figure 3 from Interleukin-34–Induced Arg1+ Macrophages Play a Key Role in Breast Cancer Brain Metastasis

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Abstract
Herceptin optical imaging of brain metastases. A, Contrast-enhanced T1- and T2-weighted MRIs of stereotaxic injection at 3 weeks after transplantation of HP organoids in C57BL/6 syngeneic mice. B, Representative BLI images of the cerebellum tumor at 3 weeks after organoid cell transplantation of HER2+ tumor organoids. C, Live animal in vivo imaging of NIR fluorophore–labeled trastuzumab (NIR-trastuzumab). Mice were injected with 100 μg of NIR-trastuzumab via the tail vein 24 hours prior to this imaging. D, Left, Brightfield images of dissected cerebellum tumor at 3 weeks after transplantation. Right, Imaging of NIR-trastuzumab after dissection. E, NIR-trastuzumab imaging was performed after 24 hours of formalin fixation of mouse brain tissues. Left, Brightfield images of formalin-fixed cerebellum tumor slices. Right, Imaging of NIR-trastuzumab after formalin fixation in the same cerebellum tumor slices.