UNSCHEDULED DNA REPAIR IN THE HUMAN CORNEA FOLLOWING SOLAR SIMULATING RADIATION

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Abstract
Following exposure to solar simulating radiation (UVB) in vitro, autoradiography with tritiated thymidine was performed in human corneae. An UVA‐irradiated and an unirradiated cornea served as controls. Sparsely labelled nuclei, indicating unscheduled thymidine‐dimer repair DNA‐synthe‐sis (dark repair) were observed in all cellular compartments of the cornea. Control specimens did not exhibit dark repair. The ratio of sparsely labelled cells and grains per nucleus were lowest in the corneal epithelium and significantly higher in the stromal cells and the endothelium.

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