Chemotherapy of acute lymphoblastic leukemia in children
Author:
- 1 January 1976
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 1 (2) , 201-209
Abstract
Between 1969‐1973, 75 consecutive children under the age of 15 years with acute lymphoblastic leukemia were treated with a multiple‐drug regimen (L‐2). Prophylaxis for meningeal leukemia was limited to the repeated intrathecal injections of methotrexate. Seventy‐four patients achieved remission; the duration of remissions could be evaluated only for 70. Relapse terminated complete remission within 1‐54 months in 21 children. Four of these relapses were confined to the central nervous system. Forty‐nine patients continue in complete remission from 23 to 63 months. Chemotherapy has been discontinued in 29 children, and 25 of these remain without evidence of recurrence for 2‐27 months posttreatment.Keywords
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