Cytotoxic 4-phenylcoumarins from the flowering buds of Mesua ferrea
- 17 November 2022
- journal article
- research article
- Published by Taylor & Francis in Natural Product Research
- Vol. 37 (22) , 3741-3750
Abstract
Eleven 4-phenylcoumarins including three new 4-phenylcoumarins, mesuaferols A–C (1–3), together with eight known 4-phenylcoumarins (4–11) have been isolated from the flowering buds of Mesua ferrea. Their structures were elucidated via UV, IR, HR-ESI-MS, and NMR spectral data. Compound 9 showed moderate cytotoxic activity toward MDA-MB-231, MCF-7, HepG2 and HeLa cell lines with IC50 values of 13.68 ± 1.36 μM, 9.27 ± 1.84 μM, 21.06 ± 1.95 μM, and 7.26 ± 1.68 μM, respectively, and other compounds showed weak cytotoxicity. Graphical AbstractKeywords
Funding Information
- National Natural Science Foundation of China (82004061)
- National College Students Innovative Experimental Training Program (202110475076)
- National Natural Science Foundation of China (U2004129)
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