p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552)
Open Access
- 16 April 2010
- Vol. 15 (4) , 2782-2790
Abstract
Four new p-aminoacetophenonic acids, named (2E)-11-(4′-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4′-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(2), (2E)-11-(4′-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4′-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 1–4 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 1–4 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn’t active against VSVG/HIV-luc pseudotyping virus.Keywords
This publication has 12 references indexed in Scilit:
- Marine natural productsNatural Product Reports, 2010
- Pyrrole and indole alkaloids from an endophyticFusarium incarnatum(HKI00504) isolated from the mangrove plantAegiceras corniculatumJournal of Asian Natural Products Research, 2008
- Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatumPhytochemistry, 2008
- Shearinines D–K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channelsTetrahedron, 2007
- New Cyclopentenone Derivatives from an Endophytic Streptomyces sp. Isolated from the Mangrove Plant Aegiceras comiculatumThe Journal of Antibiotics, 2005
- p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte: Streptomyces griseus subsp.Journal of Natural Products, 2005
- Chemical Constituents from the Mangrove Plant, Aegiceras corniculatumJournal of Natural Products, 2004
- Candicidin biosynthesis in Streptomyces griseusApplied Microbiology and Biotechnology, 2003
- Thraustochytrosides A-C: new glycosphingolipids from a unique marine protist, Thraustochytrium globosumTetrahedron Letters, 1999
- Ecology, metabolite production, and substrate utilization in endophytic fungiNatural Toxins, 1993