T-cell prolymphocytic leukemia (T-PLL) with unique surface phenotype

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Abstract
Leukemic cells of a 19 year old patient with prolymphocytic leukemia of T-cell type (T-PLL) were characterized by surface markers and immunologic functions. Phenotypic analysis using a large panel of monoclonal antibodies corresponding to the clusters (CD) of differentiation antigens established on the leukocyte Typing Workshops I and II [1, 16] revealed a unique T-cell phenotype not yet reported in the literature: CD 1 (T 6)−, CD 2 (T 11)+, CD 3 (T 3)+, CD 4 (T 4)−, CD 5 (T 1)−, CD 6 (T 411)+, CD 7 (Leu 9)+, CD 8 (T 811)−, CD 10 (J 5)−, CD 11 (M 522)+, CD 12 (M 67)−, CD 13 (My 7)−, CD 14 (Mo 2)−, CD 16 (Vep 13, 3 G 8, Leu 11)+, CD 18 (MHM 23)+, CD 19 (B 4)−, CD 20 (B 1)−, CD 25 (TAC)−, MHC-class II (HLA-DR, HLA-DQ)−, NKH 1 A+, Leu 7−. Despite the expression of surface structures associated with natural killer (NK) function (CD 16, CD 18, NKH 1 A) the T-PLL cells were inactive in NK assays in vitro. Low in vitro ADCC activity was detectable. This unusual T-PLL phenotype might help to identify a new distinct T-cell differentiation stage.

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