Thiazolo[5,4-b]pyridine Alkaloid and Seven ar-Bisabol Sesquiterpenes Produced by the Endophytic Fungus Penicillium janthinellum

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Abstract
We investigated the secondary metabolites present in Penicillium janthinellum MPT-25, an endophytic fungus isolated from Taxus wallichiana var. chinensis (Pilger) Florin. Chemical characterization of the solid cultured extract resulted in the isolation of 11 compounds, including eight previously undescribed metabolites: a thiazolo[5,4-b]pyridine alkaloid, janthinedine A (1), and seven ar-bisabol sesquiterpenes, janthinepenes A-G (2-8). Their structures were elucidated by a combination of extensive spectroscopic methods, including single-crystal X-ray diffraction and ECD spectra. The antimicrobial activities of these compounds were evaluated against seven agricultural pathogenic fungi and eight clinically drug-resistant bacteria.
Funding Information
  • Central University Basic Research Fund of China (CZQ22010, YZZ20009)
  • National Natural Science Foundation of China (31900288, 82073714)
  • National Civil Affairs Commissions young and middle-aged talents training program (MZR20008)
  • Fundamental Research Funds for the Provincial Universities of Zhejiang (2021TD001)

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