Relationship between lymphovascular invasion and molecular subtypes in invasive breast cancer

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Abstract
Purpose The aim of this study is to evaluate the relation between LVI and molecular subtypes in invasive breast cancers and to find out whether LVI which is a histopathologic indicator has a role in subtype classification or not. Methods 176 patients who had mastectomy for breast cancer between 2013 and 2018 in the Department of Surgical Oncology, Faculty of Medicine, Ankara University were retrospectively analyzed. 132 patients who had LVI, ER, PR, Her 2 and Ki‐67 index status information provided in their pathology results were included in the study. The relationship between molecular subtypes and LVI was investigated. Results 132 patients were analyzed retrospectively. 82 patients had LVI and 50 patients had not. We found a relationship between Luminal B with Her2(‐) and LVI, basal like and LVI(p=0.00). No significant statistical difference was found between LVI and other molecular subtypes. We confirmed these results with multiple variable analysis (%77,3 correlation). Conclusions As a result, we found that LVI can affect molecular subtypes. This showed that, a histopathological factor may affect tumor biology. In other words, breast cancer is a heterogeneous disease with many different predictors and prognostic variables.

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