Telomerase Activity in Cancer

Authors:
  • PVPhilippe Vielh
    Philippe Vielh
  • AEAdel K. El-Naggar
    Adel K. El-Naggar
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Abstract
Telomerase is an important enzyme required for maintenance of chromosome ends (telomeres) during cell division. Since elevated activity of telomerase has been selectively demonstrated in a large number of human cancers, it has generated considerable excitement as a potential cancer marker, a prognostic factor, and a target of possible anticancer strategy. This article details diagnostic, prognostic, and therapeutic prospects linked to the measurement of telomerase activity and the growing complexity of its regulation and function.