Expression of MMP‐7(pump‐1) mRNA in human colorectal cancers

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Abstract
The expression of MMP‐7 (pump‐1) gene was examined in 10 cases of colorectal cancer by utilizing RT‐PCR. In 9 out of 10 cases, MMP‐7 mRNA was detected in cancerous tissue, whereas none was detected in adjacent normal colon tissue. However, this message was detected in only I out of 6 colon‐cancer cell lines. In colonic mucosa from 3 patients with ulcerative colitis it was not detected. The expression of MMP‐2 (72‐kDa type‐IV collagenase) mRNA was also investigated in the same tissue samples, and was detected in all samples, including cancerous and non‐cancerous tissue. Our data suggest that MMP‐7 is expressed in a tumor‐associated manner in colorectal cancers and may play a role in tumor progression.

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