Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices

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Abstract
The design and use of new potent and specific antimicrobial systems are of crucial importance in the medical field. This will help relieve, fight, and eradicate infections and thus improve human health. The use of metals in various forms as antimicrobial therapeutics has been known since ancient times. In this sense, polymeric hydrogel matrices as multifunctional materials and in combination with various metal forms can be a great alternative to conventional treatments for infections. Hydrogels possess high hydrophilicity, specific three-dimensional networks, fine biocompatibility, and cell adhesion and are therefore suitable as materials for the loading of active antimicrobial agents and acting in antimicrobial areas. The biocompatible nature of hydrogels’ matrices makes them a convenient starting platform to develop biocompatible, selective, active controlled-release antimicrobial materials. Hydrogels based on acrylate and itaconic acid were synthesized and loaded with silver (Ag+), copper (Cu2+), and zinc (Zn2+) ions as a controlled release and antimicrobial system to test release properties and antimicrobial activity in contact with microbes. The metal ions/hydrogel systems exhibited favorable biocompatibility, release profiles, and antimicrobial activity against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Escherichia coli, and Candida albicans microbes, and have shown that they have the capacity to “fight” with the life-threatening infections. Antimicrobial activity depends on types of metal ions, the composition of polymeric matrices, as well as the types of microbes. Designed metal ions/poly(acrylate/itaconic acid) antimicrobial systems have shown to have good potential as antimicrobial therapeutics and suitable biomaterials for medical applications.

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